Comparative analysis of experimental methods to quantify animal activity in caenorhabditis elegans models of mitochondrial disease
M Lavorato, ND Mathew, N Shah… - JoVE (Journal of …, 2021 - jove.com
Caenorhabditis elegans is widely recognized for its central utility as a translational animal
model to efficiently interrogate mechanisms and therapies of diverse human diseases.
Worms are particularly well-suited for high-throughput genetic and drug screens to gain
deeper insight into therapeutic targets and therapies by exploiting their fast development
cycle, large brood size, short lifespan, microscopic transparency, low maintenance costs,
robust suite of genomic tools, mutant repositories, and experimental methodologies to …
model to efficiently interrogate mechanisms and therapies of diverse human diseases.
Worms are particularly well-suited for high-throughput genetic and drug screens to gain
deeper insight into therapeutic targets and therapies by exploiting their fast development
cycle, large brood size, short lifespan, microscopic transparency, low maintenance costs,
robust suite of genomic tools, mutant repositories, and experimental methodologies to …