Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of
energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate
animal models of primary RC dysfunction are needed to explore the effects of variation in
RC disease subtypes, tissue-specific manifestations, and major pathogenic factors
contributing to each disorder, as well as their pre-clinical response to therapeutic
candidates. We have developed a series of zebrafish (Danio rerio) models that inhibit, to …