[HTML][HTML] Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype
KM Dwyer, D Hanidziar, P Putheti, PA Hill… - American Journal of …, 2010 - Elsevier
We have shown that CD39 and CD73 are coexpressed on the surface of murine CD4+
Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg
immunosuppressive activity. We now describe that CD39, independently of CD73, is
expressed by a subset of blood-derived human CD4+ CD25+ CD127lo Treg, defined by
robust expression of Foxp3. A further distinct population of CD4+ CD39+ T lymphocytes can
be identified, which do not express CD25 and FoxP3 and exhibit the memory effector …
Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg
immunosuppressive activity. We now describe that CD39, independently of CD73, is
expressed by a subset of blood-derived human CD4+ CD25+ CD127lo Treg, defined by
robust expression of Foxp3. A further distinct population of CD4+ CD39+ T lymphocytes can
be identified, which do not express CD25 and FoxP3 and exhibit the memory effector …