[HTML][HTML] Generation and accumulation of immunosuppressive adenosine by human CD4+ CD25highFOXP3+ regulatory T cells
M Mandapathil, B Hilldorfer, MJ Szczepanski… - Journal of Biological …, 2010 - ASBMB
Naturally occurring regulatory T cells (nTreg) are crucial for maintaining tolerance to self and
thus preventing autoimmune diseases and allograft rejections. In cancer, Treg down-
regulate antitumor responses by several distinct mechanisms. This study analyzes the role
the adenosinergic pathway plays in suppressive activities of human nTreg. Human CD4+
CD25 high FOXP3+ Treg overexpress CD39 and CD73, ectonucleotidases sequentially
converting ATP into AMP and adenosine, which then binds to A 2a receptors on effector T …
thus preventing autoimmune diseases and allograft rejections. In cancer, Treg down-
regulate antitumor responses by several distinct mechanisms. This study analyzes the role
the adenosinergic pathway plays in suppressive activities of human nTreg. Human CD4+
CD25 high FOXP3+ Treg overexpress CD39 and CD73, ectonucleotidases sequentially
converting ATP into AMP and adenosine, which then binds to A 2a receptors on effector T …