Ebolaviruses are highly virulent pathogens that cause Ebola viral disease (EVD). Data from
non-human primate (NHP) models and from human survivors of EVD suggest that anti-Ebola
antibodies play an integral role in protection. Antibody-dependent cell-mediated cytotoxicity
(ADCC) is a potential mechanism through which anti-Ebola antibodies may mediate
protection. We developed a robust Ebola-specific ADCC assay for use in ongoing trials of
Ebola vaccines. Stable cell lines for inducible Zaire ebolavirus glycoprotein (EBOV GP) …