Maternal and fetal roles in bacterially induced preterm labor in the mouse
Y Filipovich, J Klein, Y Zhou, E Hirsch - American journal of obstetrics and …, 2016 - Elsevier
Background The relative roles of the mother and fetus in signaling for labor remain poorly
understood. Objective We previously demonstrated using gene knockout (KO) mice that
Escherichia coli-induced preterm delivery is completely dependent on MyD88, a toll-like
receptor adaptor protein. Here we leveraged this finding to conduct a genetic experiment
testing whether the mother, the fetus, or both signal for parturition in bacterially induced
labor. Study Design Six different maternal/fetal genotype combinations for MyD88 were …
understood. Objective We previously demonstrated using gene knockout (KO) mice that
Escherichia coli-induced preterm delivery is completely dependent on MyD88, a toll-like
receptor adaptor protein. Here we leveraged this finding to conduct a genetic experiment
testing whether the mother, the fetus, or both signal for parturition in bacterially induced
labor. Study Design Six different maternal/fetal genotype combinations for MyD88 were …