The traditional paradigm that prostaglandins (PGs) are of central importance in the initiation
of labor has been challenged. A group of investigators has recently reported that the
amniotic fluid concentrations of PGE2 and PGF2α increase only late in the course of labor
implying that 'the accumulation of prostaglandins in amniotic fluid is an after-effect of labor
and not indicative of a role of these compounds in the initiation of human parturition'. The
present study was conducted to determine whether amniotic fluid prostaglandin …