Fetal membrane architecture, aging and inflammation in pregnancy and parturition

R Menon, LS Richardson, M Lappas - Placenta, 2019 - Elsevier
Preterm birth is the single major cause of infant mortality. Short and long term outcomes for
infants are often worse in cases of preterm premature rupture of the fetal membranes
(pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as
well as the mechanisms of membrane rupture are essential if we are to develop effective
treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation
and senescence in fetal membrane biology.