Glial-endothelial crosstalk regulates blood–brain barrier function
L Cheslow, JI Alvarez - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Radial glia provide the physical scaffolding and chemical signals to support BBB
formation.•Early astrocyte development relies on mechanical and chemical cues from
ECs.•Mature astrocytes nourish the BBB through physical contact and soluble
factors.•Reactive astrocytes release BBB-enhancing and BBB-disrupting soluble
mediators.•New therapies targeting astrocytes mitigate inflammation and promote BBB
function.The blood–brain barrier (BBB) is comprised of unique endothelial cells (ECs) that …
formation.•Early astrocyte development relies on mechanical and chemical cues from
ECs.•Mature astrocytes nourish the BBB through physical contact and soluble
factors.•Reactive astrocytes release BBB-enhancing and BBB-disrupting soluble
mediators.•New therapies targeting astrocytes mitigate inflammation and promote BBB
function.The blood–brain barrier (BBB) is comprised of unique endothelial cells (ECs) that …
