[HTML][HTML] Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
The role of T-helper type 17 (Th17) responses in airway remodeling in asthma is currently
unknown. We demonstrate that both parenteral and mucosal allergen sensitization, followed
by allergen inhalation, leads to Th17-biased lung immune responses. Unlike Th17 cells
generated in vitro, lung Th17 cells did not produce tumor necrosis factor-α or interleukin (IL)-
22. Eosinophilia predominated in acute inflammation, while neutrophilia and IL-17
increased in chronic disease. Allergen-induced tolerance involved Foxp3-, Helios-, and …
unknown. We demonstrate that both parenteral and mucosal allergen sensitization, followed
by allergen inhalation, leads to Th17-biased lung immune responses. Unlike Th17 cells
generated in vitro, lung Th17 cells did not produce tumor necrosis factor-α or interleukin (IL)-
22. Eosinophilia predominated in acute inflammation, while neutrophilia and IL-17
increased in chronic disease. Allergen-induced tolerance involved Foxp3-, Helios-, and …