Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Krüppel-like factor 4 (KLF4)
S Li, Q Zhou, H He, Y Zhao, Z Liu - Journal of Biological Chemistry, 2013 - jbc.org
Peroxisome proliferator-activated receptor γ (PPARγ), a subgroup of ligand-activated
nuclear receptors, plays critical roles in cell cycle regulation, differentiation, apoptosis, and
invasion. PPARγ is involved in tumorigenesis and is a potent target for cancer therapy.
PPARγ transactivation of KLF4 has been demonstrated in various studies; however, how
PPARγ regulates KLF4 expression is not clear. In this study, we reveal that PPARγ regulates
the expression of KLF4 by binding directly to the PPAR response element (PPRE) within the …
nuclear receptors, plays critical roles in cell cycle regulation, differentiation, apoptosis, and
invasion. PPARγ is involved in tumorigenesis and is a potent target for cancer therapy.
PPARγ transactivation of KLF4 has been demonstrated in various studies; however, how
PPARγ regulates KLF4 expression is not clear. In this study, we reveal that PPARγ regulates
the expression of KLF4 by binding directly to the PPAR response element (PPRE) within the …
