Objectives Systemic sclerosis (SSc) is a complex disease of unknown aetiology in which
inflammation and fibrosis lead to multiple organ damage. There is currently no effective
therapy that can halt the progression of fibrosis or reverse it, thus studies that provide novel
insights into disease pathogenesis and identify novel potential therapeutic targets are
critically needed. Methods We used global gene expression and genome-wide DNA
methylation analyses of dermal fibroblasts (dFBs) from a unique cohort of twins discordant …