Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis
H Tsuchiya, M Ota, S Sumitomo, K Ishigaki… - Annals of the rheumatic …, 2021 - Elsevier
Objectives Synovial fibroblasts (SFs) are one of the major components of the inflamed
synovium in rheumatoid arthritis (RA). We aimed to gain insight into the pathogenic
mechanisms of SFs through elucidating the genetic contribution to molecular regulatory
networks under inflammatory condition. Methods SFs from RA and osteoarthritis (OA)
patients (n= 30 each) were stimulated with eight different cytokines (interferon (IFN)-α, IFN-γ,
tumour necrosis factor-α, interleukin (IL)-1β, IL-6/sIL-6R, IL-17, transforming growth factor …
synovium in rheumatoid arthritis (RA). We aimed to gain insight into the pathogenic
mechanisms of SFs through elucidating the genetic contribution to molecular regulatory
networks under inflammatory condition. Methods SFs from RA and osteoarthritis (OA)
patients (n= 30 each) were stimulated with eight different cytokines (interferon (IFN)-α, IFN-γ,
tumour necrosis factor-α, interleukin (IL)-1β, IL-6/sIL-6R, IL-17, transforming growth factor …
