[HTML][HTML] Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP
The Hippo signaling pathway suppresses cell proliferation and tumorigenesis. In the
canonical Hippo pathway, large tumor suppressor kinases 1/2 (LATS1/2) phosphorylate the
transcriptional coactivator yes-associated protein (YAP) and thereby suppress its nuclear
localization and co-transcriptional activity. Nuclear Dbf2-related kinases 1/2 (NDR1/2),
which are closely related to LATS1/2, also phosphorylate and inactivate YAP by suppressing
its nuclear localization. Furry (FRY) is a cytoplasmic protein that associates with NDR1/2 and …
canonical Hippo pathway, large tumor suppressor kinases 1/2 (LATS1/2) phosphorylate the
transcriptional coactivator yes-associated protein (YAP) and thereby suppress its nuclear
localization and co-transcriptional activity. Nuclear Dbf2-related kinases 1/2 (NDR1/2),
which are closely related to LATS1/2, also phosphorylate and inactivate YAP by suppressing
its nuclear localization. Furry (FRY) is a cytoplasmic protein that associates with NDR1/2 and …