Ppic modulates CCl4-induced liver fibrosis and TGF-β-caused mouse hepatic stellate cell activation and regulated by miR-137-3p
X Yang, B Shu, Y Zhou, Z Li, C He - Toxicology Letters, 2021 - Elsevier
Hepatic stellate cell activation, characterized by hyperproliferation and increased release of
collagens, is a critical event during the initiation and development of hepatic fibrosis. The
deregulated genes among different expression profiles based on online datasets were
analyzed, attempting to identify novel potential biomarkers and treatment targets for hepatic
fibrosis. The abnormal upregulation of mouse peptidylprolyl isomerase C (Ppic) within the
CCl 4-caused hepatic fibrosis model in mice was identified according to bioinformatics and …
collagens, is a critical event during the initiation and development of hepatic fibrosis. The
deregulated genes among different expression profiles based on online datasets were
analyzed, attempting to identify novel potential biomarkers and treatment targets for hepatic
fibrosis. The abnormal upregulation of mouse peptidylprolyl isomerase C (Ppic) within the
CCl 4-caused hepatic fibrosis model in mice was identified according to bioinformatics and …