[HTML][HTML] Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice

AC Luissint, HC Williams, W Kim, S Flemming… - Mucosal …, 2019 - Elsevier
Junctional adhesion molecule-A (JAM-A) is a transmembrane glycoprotein expressed on
leukocytes, endothelia, and epithelia that regulates biological processes including barrier
function and immune responses. While JAM-A has been reported to facilitate tissue
infiltration of leukocytes under inflammatory conditions, the contributions of leukocyte-
expressed JAM-A in vivo remain unresolved. We investigated the role of leukocyte-
expressed JAM-A in acute peritonitis induced by zymosan, lipopolysaccharide (LPS), or …