Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage
P Castillo, M Bogliolo, J Surralles - DNA repair, 2011 - Elsevier
Fanconi anemia (FA) and ataxia telangiectasia (AT) share common traits such chromosomal
instability and proneness to hematological cancers. Both AT and FA cell lines, and patients,
are characterized by abnormally high levels of oxidative stress markers. The key FA protein
FANCD2 is phosphorylated on Ser 222 by ATM after ionizing radiation (IR), thus allowing
normal activation of the S-phase checkpoint, and ATM cells are known to be hypersensitive
to oxidative damage. In this work we show that FANCD2 deficient cells have a defective S …
instability and proneness to hematological cancers. Both AT and FA cell lines, and patients,
are characterized by abnormally high levels of oxidative stress markers. The key FA protein
FANCD2 is phosphorylated on Ser 222 by ATM after ionizing radiation (IR), thus allowing
normal activation of the S-phase checkpoint, and ATM cells are known to be hypersensitive
to oxidative damage. In this work we show that FANCD2 deficient cells have a defective S …
