Kinomic profiling approach identifies Trk as a novel radiation modulator
JS Jarboe, JJ Jaboin, JC Anderson… - Radiotherapy and …, 2012 - Elsevier
BACKGROUND: Ionizing radiation treatment is used in over half of all cancer patients, thus
determining the mechanisms of response or resistance is critical for the development of
novel treatment approaches. MATERIALS AND METHODS: In this report, we utilize a high-
content peptide array platform that performs multiplex kinase assays with real-time kinetic
readout to investigate the mechanism of radiation response in vascular endothelial cells. We
applied this technology to irradiated human umbilical vein endothelial cells (HUVEC) …
determining the mechanisms of response or resistance is critical for the development of
novel treatment approaches. MATERIALS AND METHODS: In this report, we utilize a high-
content peptide array platform that performs multiplex kinase assays with real-time kinetic
readout to investigate the mechanism of radiation response in vascular endothelial cells. We
applied this technology to irradiated human umbilical vein endothelial cells (HUVEC) …