Insulin resistance is a major risk factor for many diseases. However, its underlying
mechanism remains unclear in part because it is triggered by a complex relationship
between multiple factors, including genes and the environment. Here, we used
metabolomics combined with computational methods to identify factors that classified insulin
resistance across individual mice derived from three different mouse strains fed two different
diets. Three inbred ILSXISS strains were fed high-fat or chow diets and subjected to …