Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in …
BM Vanaudenaerde, WA Wuyts, LJ Dupont… - The Journal of heart and …, 2003 - Elsevier
Bronchiolitis obliterans syndrome is the major constraint on the long-term survival after lung
transplantation. Both neutrophils and interleukin (IL)-8, a potent neutrophil attractant, have
been shown to play an important role in the pathophysiology of obliterative bronchiolitis. We
investigated the potential role of human airway smooth muscle cells in obliterative
bronchiolitis by studying their release of IL-8 after stimulation with IL-17, a novel T-cell–
derived chemokine capable of attracting and activating neutrophils. We demonstrated a …
transplantation. Both neutrophils and interleukin (IL)-8, a potent neutrophil attractant, have
been shown to play an important role in the pathophysiology of obliterative bronchiolitis. We
investigated the potential role of human airway smooth muscle cells in obliterative
bronchiolitis by studying their release of IL-8 after stimulation with IL-17, a novel T-cell–
derived chemokine capable of attracting and activating neutrophils. We demonstrated a …