Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts
D Saini, J Weber, S Ramachandran, D Phelan… - The Journal of heart and …, 2011 - Elsevier
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a major cause of morbidity and
mortality after lung transplantation (LTx). We sought to better understand the relationship
between alloimmune responses and autoimmunity and, subsequently, how autoimmunity
leads to chronic rejection. METHODS: We analyzed the development of donor-specific
antibodies (Abs) in LTx by flow PRA and the development of Abs to K-α1 tubulin (K-α1T) and
collagen V (ColV) by ELISA. The frequency of K-α1T-and ColV-specific T cells that secrete …
mortality after lung transplantation (LTx). We sought to better understand the relationship
between alloimmune responses and autoimmunity and, subsequently, how autoimmunity
leads to chronic rejection. METHODS: We analyzed the development of donor-specific
antibodies (Abs) in LTx by flow PRA and the development of Abs to K-α1 tubulin (K-α1T) and
collagen V (ColV) by ELISA. The frequency of K-α1T-and ColV-specific T cells that secrete …