Technique for prolonged normothermic ex vivo lung perfusion
M Cypel, JC Yeung, S Hirayama, M Rubacha… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: The inhibition of cellular metabolism induced by hypothermia obviates the
possibility of substantial reparative processes occurring during organ preservation. The aim
of this study was to develop a technique of extended (12-hour) ex vivo lung perfusion
(EVLP) at normothermia for assessment and protective maintenance of the donor lung.
METHODS: Six double-lung blocks from 35-kg pigs and 5 single human lungs were
subjected to 12 hours of normothermic EVLP using acellular Steen Solution. In the animal …
possibility of substantial reparative processes occurring during organ preservation. The aim
of this study was to develop a technique of extended (12-hour) ex vivo lung perfusion
(EVLP) at normothermia for assessment and protective maintenance of the donor lung.
METHODS: Six double-lung blocks from 35-kg pigs and 5 single human lungs were
subjected to 12 hours of normothermic EVLP using acellular Steen Solution. In the animal …