Myofibroblasts of recipient origin are not the predominant mesenchymal cell in bronchiolitis obliterans in lung allografts

SA Yousem, C Sherer, K Fuhrer… - The Journal of Heart and …, 2013 - jhltonline.org
In hematopoietic stem-cell and solid-organ transplantation, it has been suggested that
parenchymal cells of the donor are replaced by differentiated host stem cells to a variable
degree. 1 Such epithelial chimerism has been proposed in allografts of liver, kidney and
heart. In some of these donor organs, investigators have reported> 40% of donor
parenchymal epithelial cells are replaced by differentiated recipient stem cells within short
periods of time, often accelerated by acute or chronic injury to the graft. In human lung …