The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent “γ-secretase” cleavage
T Ikeuchi, SS Sisodia - Journal of Biological Chemistry, 2003 - jbc.org
The evolutionary conserved Notch signaling pathway is involved in cell fate specification
and mediated by molecular interactions between the Notch receptors and the Notch ligands,
Delta, Serrate, and Jagged. In this report, we demonstrate that like Notch, Delta1 and
Jagged2 are subject to presenilin (PS)-dependent, intramembranous" γ-secretase"
processing, resulting in the production of soluble intracellular derivatives. Moreover, and
paralleling the observation that expression of familial Alzheimer's disease-linked mutant …
and mediated by molecular interactions between the Notch receptors and the Notch ligands,
Delta, Serrate, and Jagged. In this report, we demonstrate that like Notch, Delta1 and
Jagged2 are subject to presenilin (PS)-dependent, intramembranous" γ-secretase"
processing, resulting in the production of soluble intracellular derivatives. Moreover, and
paralleling the observation that expression of familial Alzheimer's disease-linked mutant …