[HTML][HTML] The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments
The cleavage of Notch by presenilin (PS)/γ-secretase is a salient example of regulated
intramembrane proteolysis, an unusual mechanism of signal transduction. This cleavage is
preceded by the binding of protein ligands to the Notch ectodomain, activating its shedding.
We hypothesized that the Notch ligands, Delta and Jagged, themselves undergo PS-
mediated regulated intramembrane proteolysis. Here, we show that the ectodomain of
mammalian Jagged is cleaved by an A disintegrin and metalloprotease (ADAM) 17-like …
intramembrane proteolysis, an unusual mechanism of signal transduction. This cleavage is
preceded by the binding of protein ligands to the Notch ectodomain, activating its shedding.
We hypothesized that the Notch ligands, Delta and Jagged, themselves undergo PS-
mediated regulated intramembrane proteolysis. Here, we show that the ectodomain of
mammalian Jagged is cleaved by an A disintegrin and metalloprotease (ADAM) 17-like …