NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
SC Frasch, KZ Berry, R Fernandez-Boyanapalli… - Journal of Biological …, 2008 - jbc.org
Exofacial phosphatidylserine (PS) is an important ligand mediating apoptotic cell clearance
by phagocytes. Oxidation of PS fatty acyl groups (oxPS) during apoptosis reportedly
mediates recognition through scavenger receptors. Given the oxidative capacity of the
neutrophil NADPH oxidase, we sought to identify oxPS signaling species in stimulated
neutrophils. Using mass spectrometry analysis, only trace amounts of previously
characterized oxPS species were found. Conversely, 18: 1 and 18: 0 lysophosphatidylserine …
by phagocytes. Oxidation of PS fatty acyl groups (oxPS) during apoptosis reportedly
mediates recognition through scavenger receptors. Given the oxidative capacity of the
neutrophil NADPH oxidase, we sought to identify oxPS signaling species in stimulated
neutrophils. Using mass spectrometry analysis, only trace amounts of previously
characterized oxPS species were found. Conversely, 18: 1 and 18: 0 lysophosphatidylserine …
