Exploiting APC function as a novel cancer therapy
AC Lesko, KH Goss, JR Prosperi - Current drug targets, 2014 - ingentaconnect.com
AC Lesko, KH Goss, JR Prosperi
Current drug targets, 2014•ingentaconnect.comThe Adenomatous Polyposis Coli (APC) tumor suppressor is most commonly mutated in
colorectal cancers such as familial adenomatous polyposis (FAP); as well as many other
epithelial cancers like breast, pancreatic, and lung cancer. APC mutations usually result in a
truncated form of the protein lacking the carboxy-terminal region resulting in loss of function.
Mutations in APC have been identified in early stages of cancer development making it a
gatekeeper of tumor progression and therefore an ideal therapeutic target. APC is best …
colorectal cancers such as familial adenomatous polyposis (FAP); as well as many other
epithelial cancers like breast, pancreatic, and lung cancer. APC mutations usually result in a
truncated form of the protein lacking the carboxy-terminal region resulting in loss of function.
Mutations in APC have been identified in early stages of cancer development making it a
gatekeeper of tumor progression and therefore an ideal therapeutic target. APC is best …
The Adenomatous Polyposis Coli (APC) tumor suppressor is most commonly mutated in colorectal cancers such as familial adenomatous polyposis (FAP); as well as many other epithelial cancers like breast, pancreatic, and lung cancer. APC mutations usually result in a truncated form of the protein lacking the carboxy-terminal region resulting in loss of function. Mutations in APC have been identified in early stages of cancer development making it a gatekeeper of tumor progression and therefore an ideal therapeutic target. APC is best known for its role as a negative regulator of the Wnt/β -catenin pathway. However, APC also mediates several other normal cell functions independently of Wnt/β-catenin signaling such as apical-basal polarity, microtubule networks, cell cycle, DNA replication and repair, apoptosis, and cell migration. Given the vast cellular processes involving APC, the loss of these
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