Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives
Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating
mutations in a tumor suppressor gene, adenomatous polyposis coli (APC), leading to
constitutive activation of the Wnt signaling pathway. This review summarizes the roles of
somatic and germline mutations of the APC gene in hereditary as well as sporadic forms of
CRC. We also discuss the diagnostic and prognostic value of the APC gene in the …
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating
mutations in a tumor suppressor gene, adenomatous polyposis coli (APC), leading to
constitutive activation of the Wnt signaling pathway. This review summarizes the roles of
somatic and germline mutations of the APC gene in hereditary as well as sporadic forms of
CRC. We also discuss the diagnostic and prognostic value of the APC gene in the …