[PDF][PDF] Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Y Sohrabi, H Reinecke, LAB Joosten, MG Netea - Med, 2021 - cell.com
Med, 2021cell.com
Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2,
and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly
individuals. We discuss evidence suggesting that trained immunity elicited by BCG
vaccination may improve immune responses and can serve as a strategy to combat COVID-
19 in this population.
Summary
Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population.
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