[HTML][HTML] TIE2-expressing monocytes and M2-polarized macrophages impact survival and correlate with angiogenesis in adenocarcinoma of the pancreas

G Atanasov, C Pötner, G Aust, K Schierle, C Dietel… - Oncotarget, 2018 - ncbi.nlm.nih.gov
G Atanasov, C Pötner, G Aust, K Schierle, C Dietel, C Benzing, F Krenzien, M Bartels…
Oncotarget, 2018ncbi.nlm.nih.gov
Results Patients with tumors characterized by the presence of CD163+ TAMs or TEMs in
TCA or TIF, respectively, showed a significantly decreased 1-, 3-and 5-year overall and
recurrence-free survival compared to patients without CD163+ TAMs or TEMs (all ρ< 0.05).
Patients with TEMs in TCA showed a higher incidence of tumor recurrence (ρ< 0.05).
Furthermore, the presence of CD163+ TAMs was associated with a higher tumor MVD (ρ<
0.05). Conclusions Presence of M2-polarized TAMs and TEMs is associated with a …
Results
Patients with tumors characterized by the presence of CD163+ TAMs or TEMs in TCA or TIF, respectively, showed a significantly decreased 1-, 3-and 5-year overall and recurrence-free survival compared to patients without CD163+ TAMs or TEMs (all ρ< 0.05). Patients with TEMs in TCA showed a higher incidence of tumor recurrence (ρ< 0.05). Furthermore, the presence of CD163+ TAMs was associated with a higher tumor MVD (ρ< 0.05).
Conclusions
Presence of M2-polarized TAMs and TEMs is associated with a decreased overall and recurrence-free survival of patients with PDAC.
Materials and methods
The localization and density of CD163+ M2-polarized TAMs and TEMs were quantified in the tumor central area (TCA) and tumor-infiltrating front (TIF) in human PDAC tissue (n= 106) and correlated to clinicopathological characteristics, tumor recurrence rates and patient survival. In parallel, tumor microvascular density (MVD) and the density of angiopoietin-positive tumor cells were quantified. Statistical analysis was performed using SPSS software.
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