[HTML][HTML] Characterization of the testis-specific proteasome subunit α4s in mammals
The 26 S proteasome is responsible for regulated proteolysis in eukaryotic cells. It is
composed of one 20 S core particle (CP) flanked by one or two 19 S regulatory particles.
The CP is composed of seven different α-type subunits (α1-α7) and seven different β-type
subunits, three of which are catalytic. Vertebrates encode four additional catalytic β subunits
that are expressed predominantly in immune tissues and produce distinct subtypes of CPs
particularly well suited for the acquired immune system. In contrast, the diversity of α …
composed of one 20 S core particle (CP) flanked by one or two 19 S regulatory particles.
The CP is composed of seven different α-type subunits (α1-α7) and seven different β-type
subunits, three of which are catalytic. Vertebrates encode four additional catalytic β subunits
that are expressed predominantly in immune tissues and produce distinct subtypes of CPs
particularly well suited for the acquired immune system. In contrast, the diversity of α …