Pharmacokinetics of levodopa in patients with Parkinson disease and motor fluctuations depending on the presence of Helicobacter pylori infection
E Narozanska, M Bialecka… - Clinical …, 2014 - journals.lww.com
Background According to recent investigations, the eradication of Helicobacter pylori (H.
pylori) may influence levodopa (LD) pharmacokinetics (PK) and improve the motor function
of infected patients with Parkinson disease (PD). The aim of this study was to compare PK of
LD and its metabolite 3-O-methyldopa (3-OMD), between H. pylori-positive (HP+) and-
negative (HP−) patients with PD and motor fluctuations. Materials and Methods Patients with
the clinical diagnosis of PD, under stable LD therapy, reporting daily motor fluctuations and …
pylori) may influence levodopa (LD) pharmacokinetics (PK) and improve the motor function
of infected patients with Parkinson disease (PD). The aim of this study was to compare PK of
LD and its metabolite 3-O-methyldopa (3-OMD), between H. pylori-positive (HP+) and-
negative (HP−) patients with PD and motor fluctuations. Materials and Methods Patients with
the clinical diagnosis of PD, under stable LD therapy, reporting daily motor fluctuations and …