Focal adhesion kinase versus p53: apoptosis or survival?

WG Cance, VM Golubovskaya - Science signaling, 2008 - science.org
WG Cance, VM Golubovskaya
Science signaling, 2008science.org
Focal adhesion kinase (FAK) is a tyrosine kinase that interacts with a multitude of signaling
partners and helps cells to survive in the face of various proapoptotic signals. One of the
most important interactions for FAK is with the tumor suppressor protein p53. p53 binds not
only to the amino-terminal domain of FAK but also to the FAK promoter to inhibit its
transcription. A study now reports the biological implications of the kinase-independent
interaction of FAK with p53, which opens up future perspectives in cell signaling and cancer …
Focal adhesion kinase (FAK) is a tyrosine kinase that interacts with a multitude of signaling partners and helps cells to survive in the face of various proapoptotic signals. One of the most important interactions for FAK is with the tumor suppressor protein p53. p53 binds not only to the amino-terminal domain of FAK but also to the FAK promoter to inhibit its transcription. A study now reports the biological implications of the kinase-independent interaction of FAK with p53, which opens up future perspectives in cell signaling and cancer research. We focus on FAK and p53 signaling, which link signal transduction pathways from the extracellular matrix and cytoplasm to the nucleus, in human and mouse cells. FAK is proposed to be a critical scaffold protein that sequesters proapoptotic proteins, such as p53, to mediate cell survival.
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