The cytokine network in chronic obstructive pulmonary disease

PJ Barnes - American journal of respiratory cell and molecular …, 2009 - atsjournals.org
American journal of respiratory cell and molecular biology, 2009atsjournals.org
Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway
diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation
and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of
inflammation, whereas proinflammatory cytokines amplify and perpetuate the inflammatory
response. Multiple chemokines recruit inflammatory cells from the circulation into the lungs
and many growth factors maintain this inflammation and lead to characteristic structural …
Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells. Lymphokines secreted from T cells regulate the pattern of inflammation, whereas proinflammatory cytokines amplify and perpetuate the inflammatory response. Multiple chemokines recruit inflammatory cells from the circulation into the lungs and many growth factors maintain this inflammation and lead to characteristic structural changes in the airways. There are several therapeutic approaches that target cytokine-mediated inflammation in chronic obstructive pulmonary disease, but blocking specific cytokines may not provide clinical benefit, whereas broad-spectrum anti-inflammatory approaches are more likely to be clinically effective.
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