[HTML][HTML] IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia
T Aoyagi, MW Newstead, X Zeng, SL Kunkel… - Mucosal …, 2017 - Elsevier
Influenza virus causes a respiratory disease in humans that can progress to lung injury with
fatal outcome. The interleukin (IL)-36 cytokines are newly described IL-1 family cytokines
that promote inflammatory responses via binding to the IL-36 receptor (IL-36R). The
mechanism of expression and the role of IL-36 cytokines are poorly understood. Here, we
investigated the role of IL-36 cytokines in modulating the innate inflammatory response
during influenza virus-induced pneumonia in mice. The intranasal administration of …
fatal outcome. The interleukin (IL)-36 cytokines are newly described IL-1 family cytokines
that promote inflammatory responses via binding to the IL-36 receptor (IL-36R). The
mechanism of expression and the role of IL-36 cytokines are poorly understood. Here, we
investigated the role of IL-36 cytokines in modulating the innate inflammatory response
during influenza virus-induced pneumonia in mice. The intranasal administration of …