[HTML][HTML] Cytosolic dsDNA is a novel senescence marker associated with pyroptosis activation
R Zhou, X Xie, Z Qin, X Li, J Liu, H Li, Q Zheng, Y Luo - Tissue and Cell, 2021 - Elsevier
Cellular senescence has become a research focus because of its dual roles in ageing and
tumorigenesis. The biomarkers of senescence are essential for detecting senescent cells
and understanding the ageing process and its regulation. Here, we identify cytosolic double-
stranded DNA (dsDNA) as a novel sensitive biomarker for cellular senescence of mouse
embryonic fibroblasts (MEFs) in response to common types of stimuli, including replicative
stress, genetic modification and oxidative stress. We found that the accumulation of cytosolic …
tumorigenesis. The biomarkers of senescence are essential for detecting senescent cells
and understanding the ageing process and its regulation. Here, we identify cytosolic double-
stranded DNA (dsDNA) as a novel sensitive biomarker for cellular senescence of mouse
embryonic fibroblasts (MEFs) in response to common types of stimuli, including replicative
stress, genetic modification and oxidative stress. We found that the accumulation of cytosolic …
