Cilia in vertebrate development and disease
EC Oh, N Katsanis - Development, 2012 - journals.biologists.com
Development, 2012•journals.biologists.com
Through the combined study of model organisms, cell biology, cell signaling and medical
genetics we have significantly increased our understanding of the structure and functions of
the vertebrate cilium. This ancient organelle has now emerged as a crucial component of
certain signaling and sensory perception pathways in both developmental and homeostatic
contexts. Here, we provide a snapshot of the structure, function and distribution of the
vertebrate cilium and of the pathologies that are associated with its dysfunction.
genetics we have significantly increased our understanding of the structure and functions of
the vertebrate cilium. This ancient organelle has now emerged as a crucial component of
certain signaling and sensory perception pathways in both developmental and homeostatic
contexts. Here, we provide a snapshot of the structure, function and distribution of the
vertebrate cilium and of the pathologies that are associated with its dysfunction.
Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.
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