Enhanced isolation of adult thymic epithelial cell subsets for multiparameter flow cytometry and gene expression analysis

BT McLelland, D Gravano, J Castillo, S Montoy… - Journal of …, 2011 - Elsevier
The epithelial cells (TECs) are microenvironmental niche cells which support T lymphocyte
development in the thymus. Most studies of TEC biology have focused on TEC at the fetal
stage of development, whereas the biology of adult-stage TECs is not as well-understood.
Delineating the molecular mechanisms that control adult TEC differentiation has implications
for the success of T-lymphocyte based therapies for autoimmune diseases and induction of
immunological tolerance to stem cell-derived tissues. Detailed analysis of adult TECs is …