Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation
E Velardi, JA Dudakov, MRM van den Brink - Immunology letters, 2013 - Elsevier
The thymus is particularly sensitive to injury caused by cytoreductive chemo-or radiation
therapy, shock, infection and graft versus host disease. Insufficient thymic recovery has been
directly correlated with increased risk of opportunistic infections and poor clinical outcomes
in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Prolonged
immune deficiency is particularly pronounced in older patients whose thymi are already
significantly impaired due to age-related thymic involution. Preclinical and clinical studies …
therapy, shock, infection and graft versus host disease. Insufficient thymic recovery has been
directly correlated with increased risk of opportunistic infections and poor clinical outcomes
in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Prolonged
immune deficiency is particularly pronounced in older patients whose thymi are already
significantly impaired due to age-related thymic involution. Preclinical and clinical studies …
