Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis
(MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of
previously suggested candidate genes of energy metabolism (Complex I genes located in
the nucleus and in the mitochondria) in patients with MS relative to ethnically matched SLE
patients and healthy controls. After stringent correction for multiple testing, we reproduce the
association of the mitochondrial (mt) DNA haplotype K⁎ with MS, but reject the importance …