[HTML][HTML] Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages
G Chen, CS Tan, BK Teh, J Lu - Journal of Biological Chemistry, 2011 - ASBMB
Hereditary homozygous C1q deficiency is rare, but it almost certainly causes systemic lupus
erythematosus. On the other hand, C1q levels can decline in systemic lupus erythematosus
patients without apparent C1q gene defects and the versatility in C1q production is a likely
cause. As an 18-subunit protein, C1q is assembled in a 1: 1: 1 ratio from three different
subunits. The three human C1q genes are closely bundled on chromosome 1 (C1qA-C1qC-
C1qB) and their basal and IFNγ-stimulated expression, largely restricted to macrophages …
erythematosus. On the other hand, C1q levels can decline in systemic lupus erythematosus
patients without apparent C1q gene defects and the versatility in C1q production is a likely
cause. As an 18-subunit protein, C1q is assembled in a 1: 1: 1 ratio from three different
subunits. The three human C1q genes are closely bundled on chromosome 1 (C1qA-C1qC-
C1qB) and their basal and IFNγ-stimulated expression, largely restricted to macrophages …