Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein
GJ Nuovo, C Magro, T Shaffer, H Awad, D Suster… - Annals of diagnostic …, 2021 - Elsevier
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13
autopsies of people who died of COVID-19 were examined. Cultured endothelial and
neuronal cells were incubated with and wild type mice were injected IV with different spike
subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response.
In 13/13 brains from fatal COVID-19, pseudovirions (spike, envelope, and membrane
proteins without viral RNA) were present in the endothelia of microvessels ranging from 0 to …
autopsies of people who died of COVID-19 were examined. Cultured endothelial and
neuronal cells were incubated with and wild type mice were injected IV with different spike
subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response.
In 13/13 brains from fatal COVID-19, pseudovirions (spike, envelope, and membrane
proteins without viral RNA) were present in the endothelia of microvessels ranging from 0 to …
