Status epilepticus (SE) is a major neurological disorder and SE survivors often develop
acquired epilepsy and cognitive deficits. Thus, it is important to stop SE and limit brain
damage. However, rapid pharmacoresistance develops to anticonvulsants as seizure
duration lengthens. Recently, acetaminophen was reported to increase endocannabinoid
levels by its conversion to AM 404. Further, cannabinoids are potent anticonvulsants. Here
we investigated whether acetaminophen would block SE-like activity in hippocampal …