[HTML][HTML] Hepatic mitochondrial defects in a nonalcoholic fatty liver disease mouse model are associated with increased degradation of oxidative phosphorylation …
Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic mitochondrial
dysfunction characterized by reduced ATP synthesis. We applied the 2 H 2 O-metabolic
labeling approach to test the hypothesis that the reduced stability of oxidative
phosphorylation proteins contributes to mitochondrial dysfunction in a diet-induced mouse
model of NAFLD. A high fat diet containing cholesterol (a so-called Western diet (WD)) led to
hepatic oxidative stress, steatosis, inflammation and mild fibrosis, all markers of NAFLD, in …
dysfunction characterized by reduced ATP synthesis. We applied the 2 H 2 O-metabolic
labeling approach to test the hypothesis that the reduced stability of oxidative
phosphorylation proteins contributes to mitochondrial dysfunction in a diet-induced mouse
model of NAFLD. A high fat diet containing cholesterol (a so-called Western diet (WD)) led to
hepatic oxidative stress, steatosis, inflammation and mild fibrosis, all markers of NAFLD, in …