Fibronectin impedes “myelin” sheet-directed flow in oligodendrocytes: a role for a beta 1 integrin-mediated PKC signaling pathway in vesicular trafficking
Z Šišková, W Baron, H de Vries, D Hoekstra - Molecular and Cellular …, 2006 - Elsevier
Differentiation of oligodendrocytes results in the formation of the myelin sheath, a dramatic
morphological alteration that accompanies cell specialization. Here, we demonstrate that
changes in the extracellular microenvironment may regulate these morphological changes
by altering intracellular vesicular trafficking of myelin sheet-directed proteins. The data
reveal that fibronectin, in contrast to laminin-2, decreased membrane-directed transport of
endogenous NCAM 140 and the model viral protein VSV G, both proteins normally residing …
morphological alteration that accompanies cell specialization. Here, we demonstrate that
changes in the extracellular microenvironment may regulate these morphological changes
by altering intracellular vesicular trafficking of myelin sheet-directed proteins. The data
reveal that fibronectin, in contrast to laminin-2, decreased membrane-directed transport of
endogenous NCAM 140 and the model viral protein VSV G, both proteins normally residing …
