[HTML][HTML] Biomarkers of browning of white adipose tissue and their regulation during exercise-and diet-induced weight loss

A Nakhuda, AR Josse, V Gburcik, H Crossland… - The American journal of …, 2016 - Elsevier
Background: A hypothesis exists whereby an exercise-or dietary-induced negative energy
balance reduces human subcutaneous white adipose tissue (scWAT) mass through the
formation of brown-like adipocyte (brite) cells. However, the validity of biomarkers of brite
formation has not been robustly evaluated in humans, and clinical data that link brite
formation and weight loss are sparse. Objectives: We used rosiglitazone and primary
adipocytes to stringently evaluate a set of biomarkers for brite formation and determined …