Importance Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can
include dermoscopic evaluation, biopsy, and histopathologic examination. Recent
translation of multiphoton microscopy (MPM) to clinical practice raises the possibility of
noninvasive, label-free in vivo imaging of BCCs that could reduce the time from consultation
to treatment. Objectives To demonstrate the capability of MPM to image in vivo BCC lesions
in human skin, and to evaluate if histopathologic criteria can be identified in MPM images …