Effect of NSAIDs on bone healing rates: a meta-analysis
BM Wheatley, KE Nappo, DL Christensen… - JAAOS-Journal of the …, 2019 - journals.lww.com
BM Wheatley, KE Nappo, DL Christensen, AM Holman, DI Brooks, BK Potter
JAAOS-Journal of the American Academy of Orthopaedic Surgeons, 2019•journals.lww.comMethods: We systematically reviewed the literature reporting the effect of NSAIDs on bone
healing. We included studies of pediatric and adult patients NSAID exposure and healing
bone. The outcomes of interest were delayed union, nonunion, or pseudarthrosis with at
least six months of follow-up. A maximum likelihood random-effects model was used to
conduct meta-analysis and meta-regression. Results: NSAID exposure increased delayed
union or nonunion (odds ratio [OR], 2.07; confidence interval [CI], 1.19 to 3.61). No effect …
healing. We included studies of pediatric and adult patients NSAID exposure and healing
bone. The outcomes of interest were delayed union, nonunion, or pseudarthrosis with at
least six months of follow-up. A maximum likelihood random-effects model was used to
conduct meta-analysis and meta-regression. Results: NSAID exposure increased delayed
union or nonunion (odds ratio [OR], 2.07; confidence interval [CI], 1.19 to 3.61). No effect …
Methods:
We systematically reviewed the literature reporting the effect of NSAIDs on bone healing. We included studies of pediatric and adult patients NSAID exposure and healing bone. The outcomes of interest were delayed union, nonunion, or pseudarthrosis with at least six months of follow-up. A maximum likelihood random-effects model was used to conduct meta-analysis and meta-regression.
Results:
NSAID exposure increased delayed union or nonunion (odds ratio [OR], 2.07; confidence interval [CI], 1.19 to 3.61). No effect was noted in pediatrics (OR, 0.58; CI, 0.27 to 1.21) or low dose/short duration of exposure (OR, 1.68; CI, 0.63 to 4.46).
Conclusion:
Analysis of the literature indicates a negative effect of NSAIDs on bone healing. In pediatric patients, NSAIDs did not have a significant effect. The effect may be dose or time dependent because low-dose/short-duration exposure did not affect union rates.
Lippincott Williams & Wilkins