Heterotopic ossification (HO) is a benign condition of abnormal formation of bone in soft
tissue. HO is frequently asymptomatic, though when it is more severe it typically manifests as
decreased range of motion at a nearby joint. HO has been recognized to occur in three
distinct contexts—trauma, neurologic injury, and genetic abnormalities. The etiology of HO is
incompletely understood. A posited theory is that HO results from the presence of
osteoprogenitor cells pathologically induced by an imbalance in local or systemic factors …