The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses
MK Gately, LM Renzetti, J Magram… - Annual review of …, 1998 - annualreviews.org
▪ Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in
promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its
activities are mediated through a high-affinity receptor composed of two subunits,
designated β1 and β2. Of these two subunits, β2 is more restricted in its distribution, and
regulation of its expression is likely a central mechanism by which IL-12 responsiveness is
controlled. Studies with neutralizing anti-IL-12 antibodies and IL-12-deficient mice have …
promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its
activities are mediated through a high-affinity receptor composed of two subunits,
designated β1 and β2. Of these two subunits, β2 is more restricted in its distribution, and
regulation of its expression is likely a central mechanism by which IL-12 responsiveness is
controlled. Studies with neutralizing anti-IL-12 antibodies and IL-12-deficient mice have …
